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Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Vertebral Osteomyelitis Cases Complicated by Bacteremia Treated with High-Dose Daptomycin and Trimethoprim-Sulfamethoxazole
Avery, Lisa M. Steed, Molly E. Woodruff, Ashley E. Hasan, Muhammad Rybak, Michael J.
Avery, Lisa M.
Steed, Molly E.
Woodruff, Ashley E.
Hasan, Muhammad
Rybak, Michael J.
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Abstract
We report two cases of daptomycin (DAP)-nonsusceptible (DNS) vancomycin-intermediate Staphylococcus aureus (VISA) vertebral osteomyelitis cases complicated by bacteremia treated with high-dose daptomycin and trimethoprim-sulfamethoxazole. Both patients responded rapidly and favorably to this combination. The clinical isolates from the two patients were tested post hoc in an in vitro pharmacokinetic/pharmacodynamic (PK/PD) model to confirm the bactericidal activity and enhancement of daptomycin and trimethoprim-sulfamethoxazole. The combination of high-dose daptomycin and trimethoprim-sulfamethoxazole should be explored further for the treatment of DNS VISA strains.
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2012-11
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American Society for Microbiology
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Avery et. al. "Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Vertebral Osteomyelitis Cases Complicated by Bacteremia Treated with High-Dose Daptomycin and Trimethoprim-Sulfamethoxazole." Antimicrob. Agents Chemother. November 2012 vol. 56 no. 11 5990-5993
http://dx.doi.org/10.1128/AAC.01046-12