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Protection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Composition
Wright, Laura E. Frye, Jennifer B. Timmermann, Barbara N. Funk, Janet L.
Wright, Laura E.
Frye, Jennifer B.
Timmermann, Barbara N.
Funk, Janet L.
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Abstract
Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60mg/kg 3x per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy x-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by micro-computerized tomography (μCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor.
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This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/jf101873f
Date
2010-09-08
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American Chemical Society
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Timmermann_2010.pdf
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Turmeric, Curcuma longa L, Curcuminoids, Ovariectomy, Bone mineral density, Bone ìCT
Citation
Wright, L. E., Frye, J. B., Timmermann, B. N., & Funk, J. L. (2010). Protection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Composition. Journal of Agricultural and Food Chemistry, 58(17), 9498–9504. http://doi.org/10.1021/jf101873f.