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Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
Aksenov, Alexander V. Grishin, Igor Yu. Aksenov, Nicolai A. Malyuga, Vladimir V. Aksenov, Dmitrii A. Nobi, Mezvah A. Rubin, Michael
Aksenov, Alexander V.
Grishin, Igor Yu.
Aksenov, Nicolai A.
Malyuga, Vladimir V.
Aksenov, Dmitrii A.
Nobi, Mezvah A.
Rubin, Michael
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Abstract
Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.
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Date
2021-07-14
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Publisher
MDPI
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Keywords
Nitroalkanes, Heterocyclic compounds, Quinozalines, Annulation
Citation
Aksenov, A.V.; Grishin, I.Y.; Aksenov, N.A.; Malyuga, V.V.; Aksenov, D.A.; Nobi, M.A.; Rubin, M. Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines. Molecules 2021, 26, 4274. https://doi.org/10.3390/molecules26144274