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A review of microdialysis coupled to microchip electrophoresis for monitoring biological events
Saylor, Rachel Ann Lunte, Susan M.
Saylor, Rachel Ann
Lunte, Susan M.
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Abstract
Microdialysis is a powerful sampling technique that enables monitoring of dynamic processes in vitro and in vivo. The combination of microdialysis with chromatographic or electrophoretic methods yields along with selective detection methods yields a “separation-based sensor” capable of monitoring multiple analytes in near real time. Analysis of microdialysis samples requires techniques that are fast (<1 min), have low volume requirements (nL–pL), and, ideally, can be employed on-line. Microchip electrophoresis fulfills these requirements and also permits the possibility of integrating sample preparation and manipulation with detection strategies directly on-chip. Microdialysis coupled to microchip electrophoresis has been employed for monitoring biological events in vivo and in vitro. This review discusses technical considerations for coupling microdialysis sampling and microchip electrophoresis, including various interface designs, and current applications in the field.
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Date
2015-02-20
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Elsevier
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Keywords
Microdialysis, Electrophoresis, Microfluidics, Sensor, In vivo monitoring, Lab-on-a-chip, Electrochemical dectection
Citation
Saylor, R. A., & Lunte, S. M. (2015). A review of microdialysis coupled to microchip electrophoresis for monitoring biological events. Journal of Chromatography. A, 1382, 48–64. http://doi.org/10.1016/j.chroma.2014.12.086