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Intramolecular oxa-Michael and Baylis Hillman Strategies towards Sultam Libraries

Knudtson, Christopher Anton
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Abstract
The utilization of Baylis-Hillman and oxa-Michael methodologies for the synthesis of sultam (cyclic sulfonamides) libraries from chiral non-racemic amino alcohols and epoxides is reported. These strategies employ a divergent synthetic approach utilizing a central vinyl sulfonamide linchpin and a variety of functional group pairing reactions to generate skeletally diverse sultam scaffolds with a variety of functionalizable handles. A variety of 5, 6, 7, and 8-member sultams are accessible through these methods with excellent diastereoselectivity, yields, and purities. In addition, the oxa-Michael protocol has been utilized in a one-pot protocol for the synthesis of alibrary of 4,4-dioxo-1,4,5-oxathiazepines.
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2011-05-31
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University of Kansas
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Chemistry Dissertations and Theses
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Knudtson_ku_0099M_11525_DATA_1.pdf
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Chemistry
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https://hdl.handle.net/1808/10706
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