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The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

Jiang, Beichen
; 
Moskovitz, Jackob
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Abstract
This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2018-09-18
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MDPI
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Pharmacy Scholarly Works
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Jiang_2018.pdf
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Keywords
Methionine sulfoxide reductase, Methionine oxidation, Oxidative stress
Citation
Jiang, B., & Moskovitz, J. (2018). The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases. Antioxidants (Basel, Switzerland), 7(9), 122. https://doi.org/10.3390/antiox7090122
URI
https://hdl.handle.net/1808/30953
DOI
10.3390/antiox7090122
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