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Visual attention and autistic behavior in infants with fragile X syndrome
Roberts, Jane E. Hatton, Deborah D. Bailey, Donald Long, Anna C. J. Anello, Vittoria Colombo, John
Roberts, Jane E.
Hatton, Deborah D.
Bailey, Donald
Long, Anna C. J.
Anello, Vittoria
Colombo, John
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Abstract
Fragile X syndrome (FXS) is the leading known inherited cause of intellectual disability and the most common known biological cause of autism. Approximately 25% to 50% of males with FXS meet full diagnostic criteria for autism. Despite the high comorbidity between FXS and autism and the ability to diagnose FXS prenatally or at birth, no studies have examined indicators of autism in infants with FXS. The current study focused on indices of visual attention, one of the earliest and most robust behavioral indicators of autism in idiopathic (non-FXS) autism. Analyses revealed lower HR variability, shallower HR decelerations, and prolonged look durations in 12-month old infants with FXS that were correlated with severity of autistic behavior but not mental age.
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Date
2012-06
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Publisher
Springer Verlag
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Keywords
Fragile X, Autism, Early detection, Heart rate, Visual attention, High-risk infants
Citation
Roberts, J. E., Hatton, D. D., Bailey, D., Long, A. C. J., Anello, V., & Colombo, J. (2012). Visual attention and autistic behavior in infants with fragile X syndrome. Journal of Autism and Developmental Disorders, 42(6), 937–946. http://doi.org/10.1007/s10803-011-1316-8