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Salient features of the aza-Wacker cyclization reaction

Thomas, Annu Anna
; 
Nagamalla, Someshwar
; 
Sathyamoorthi, Shyam
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Abstract
The intramolecular aza-Wacker reaction has unparalleled potential for the site-selective amination of olefins, but it is perhaps underappreciated relative to other alkene oxidations. The first part of this review makes the distinction between classical and tethered aza-Wacker cyclization reactions and summarizes examples of the latter. The second portion focuses on developments in asymmetric aza-Wacker cyclization technology. The final part of the review summarizes applications of all classes of aza-Wacker cyclization reactions to natural product assembly.
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Date
2020-07-21
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Royal Society of Chemistry
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Medicinal Chemistry Scholarly Works
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Thomas, A. A., Nagamalla, S., & Sathyamoorthi, S. (2020). Salient features of the aza-Wacker cyclization reaction. Chemical science, 11(31), 8073–8088. https://doi.org/10.1039/d0sc02554b
URI
https://hdl.handle.net/1808/32305
DOI
10.1039/d0sc02554b
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