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RAGE: A journey from the complications of diabetes to disorders of the nervous system – striking a fine balance between injury and repair
Rong, Ling Ling Gooch, Clifton Szabolcs, Mattias Herold, Kevan C. Lalla, Evanthia Hays, Arthur P. Yan, Shi Fang Yan, Shirley ShiDu Schmidt, Ann Marie
Rong, Ling Ling
Gooch, Clifton
Szabolcs, Mattias
Herold, Kevan C.
Lalla, Evanthia
Hays, Arthur P.
Yan, Shi Fang
Yan, Shirley ShiDu
Schmidt, Ann Marie
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Abstract
The Receptor for Advanced Glycation End Products (RAGE) is a multiligand member of the immunoglobulin superfamily. RAGE interacts with AGEs, the products of nonenzymatic glycation/oxidation of proteins and lipids that accumulate in diverse settings, such as diabetes, inflammation, renal failure, pro-oxidant states and natural aging. In addition, RAGE is also a receptor for amyloid-β peptide and β-sheet fibril species. Recent studies underscore the premise that RAGE interacts with pro-inflammatory molecules, including S100/calgranulins and amphoterin, the latter also known as high mobility group box 1 (HMGB1). In chronic neurodegenerative disorders as well as in nerve tissue upon acute injury, evidence points to upregulation of both RAGE and these ligand families. In this review, we will discuss the implications of transient/self-limited upregulation of RAGE and its ligands, vs sustained/chronic upregulation of this axis in neurodegeneration vs repair in both the central and peripheral nervous systems. Experimental evidence supports the premise that RAGE bears both homeostatic and injurious properties in the nervous system, thereby highlighting "yin/yang" features of this receptor and its ligand families.
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This is the published version. Copyright 2005 IOS Press.
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2005
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IOS Press
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Rong, Ling Ling, Clifton Gooch, Mattias Szabolcs, Kevan C Herold, Evanthia Lalla, Arthur P Hays, Shi Fang Yan, Shirley ShiDu Yan, Ann Marie Schmidt. "RAGE: A Journey from the Complications of Diabetes to Disorders of the Nervous System – Striking a Fine Balance between Injury and Repair." Restorative Neurology and Neuroscience 23.5, 6 (2005): 355-65. Web. 28 May 2015. Wb.