Thumbnail Image
Publication

Inhibition of ICAM-1/LFA-1-mediated Heterotypic T-cell Adhesion to Epithelial Cells: Design of ICAM-1 Cyclic Peptides

Anderson, Meagan E.
; 
Yakovleva, Tatyana
; 
Yongbo, Hu
; 
Siahaan, Teruna J.
Citations
Altmetric:
Abstract
In this work, we have designed cyclic peptides (cIBL, cIBR, cIBC, CH4 and CH7) derived from the parent IB peptide (ICAM-11–21) that are inhibitors of ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers. Cyclic peptide cIBR has the best activity of any of the peptides evaluated. The active ICAM-1 peptides have a common Pro-Arg-Gly sequence that may be important for binding to LFA-1.
Description
DOI: 10.1016/j.bmcl.2003.09.100
Date
2004-03
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Collections
Pharmaceutical Chemistry Scholarly Works
Show all metadata
Files
Thumbnail Image
siahaan_AFD_inhibitionofICAM.pdf
Adobe PDF, 192.13 KB
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
M.E. Anderson, T. Yakovleva, Y. Hu, and T. J. Siahaan, "Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: Design of ICAM-1 cyclic peptides," Bioorg. Med. Chem. Lett. 14, 1399–1402 (2004). [PMID: 15006370] http://dx.doi.org/10.1016/j.bmcl.2003.09.100
URI
https://hdl.handle.net/1808/7704
DOI
10.1016/j.bmcl.2003.09.100
Embedded videos