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HLA Genes in Populations of the Aleutian Islands
Rey, Diego Areces, Cristina Parga-Lozano, Carlos Gómez-Prieto, Pablo Crawford, Michael H. Arnaiz-Villena, Antonio
Rey, Diego
Areces, Cristina
Parga-Lozano, Carlos
Gómez-Prieto, Pablo
Crawford, Michael H.
Arnaiz-Villena, Antonio
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Abstract
We typed a subset of the Aleut population for HLA loci (HLA-A, HLA-B, HLA-DRB1, HLA-DQB1) to obtain an HLA profile, which was compared to other Eurasian and Amerindian populations for studying Aleut origin and its significance on the peopling of the Americas. Allele frequencies at the four loci were identified in an Aleut sample using standard indirect DNA sequencing methods. Genetic distances with Amerindians and Eurasians were obtained by comparing Aleut allele frequencies with a worldwide population database (13,164 chromosomes). The most frequently extended HLA haplotypes were also calculated. We also generated Aleut relatedness dendrograms and calculated correspondence relatedness in a multidimensional scale. Both neighbor-joining dendrograms and correspondence analysis separated Aleuts from Eskimos and Amerindians. Aleuts are closer genetically to Europeans, including Scandinavians and English. Our results are concordant with those obtained by Y-chromosome analysis, suggesting that most male Aleut ancestors of our sample came mainly from Europe.
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This is the publisher's version, also available electronically from http://digitalcommons.wayne.edu/humbiol/vol82/iss5/13/.
Date
2010-10-01
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Wayne State University Press
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Keywords
Aleuts, Amerindians, Europeans, Finns, Hla
Citation
Rey, Diego; Areces, Cristina; Parga-Lozano, Carlos; Gómez-Prieto, Pablo; Crawford, Michael H.; and Arnaiz-Villena, Antonio (2010) "HLA Genes in Populations of the Aleutian Islands," Human Biology: Vol. 82: Iss. 5-6, Article 13. http://digitalcommons.wayne.edu/humbiol/vol82/iss5/13