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Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems
Rong, Panying Yunusova, Yana Wang, Jun Zinman, Lorne Pattee, Gary L. Berry, James D. Perry, Bridget Green, Jordan R.
Rong, Panying
Yunusova, Yana
Wang, Jun
Zinman, Lorne
Pattee, Gary L.
Berry, James D.
Perry, Bridget
Green, Jordan R.
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Abstract
Purpose:
To determine the mechanisms of speech intelligibility impairment due to neurologic impairments, intelligibility decline was modeled as a function of co-occurring changes in the articulatory, resonatory, phonatory, and respiratory subsystems.
Method:
Sixty-six individuals diagnosed with amyotrophic lateral sclerosis (ALS) were studied longitudinally. The disease-related changes in articulatory, resonatory, phonatory, and respiratory subsystems were quantified using multiple instrumental measures, which were subjected to a principal component analysis and mixed effects models to derive a set of speech subsystem predictors. A stepwise approach was used to select the best set of subsystem predictors to model the overall decline in intelligibility.
Results:
Intelligibility was modeled as a function of five predictors that corresponded to velocities of lip and jaw movements (articulatory), number of syllable repetitions in the alternating motion rate task (articulatory), nasal airflow (resonatory), maximum fundamental frequency (phonatory), and speech pauses (respiratory). The model accounted for 95.6% of the variance in intelligibility, among which the articulatory predictors showed the most substantial independent contribution (57.7%).
Conclusion:
Articulatory impairments characterized by reduced velocities of lip and jaw movements and resonatory impairments characterized by increased nasal airflow served as the subsystem predictors of the longitudinal decline of speech intelligibility in ALS. Declines in maximum performance tasks such as the alternating motion rate preceded declines in intelligibility, thus serving as early predictors of bulbar dysfunction. Following the rapid decline in speech intelligibility, a precipitous decline in maximum performance tasks subsequently occurred.
Description
This research was supported by the following grants: National Institute of Health— National Institute of Deafness and Other
Communication Disorders (http://www.nidcd.nih.gov/Pages/default.aspx) Grants R01 DC009890 & R01 DC0135470 (PI: JG); ALS Society of Canada (https://www.als.ca/en) Denise Ramsay Discovery Grant (PI:YY); Canadian Institute of Health Research (http://
www.cihr-irsc.gc.ca/e/47631.html) CIHR Planning Grant FRN126682 (PI: YY). The funders had no role n study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Date
2016-05-05
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Public Library of Science
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Keywords
Speech, Jaw, Amyotrophic lateral sclerosis, Syllables, Cognitive impairment, Bioacousitcs, Aerodynamics, Principal component analysis
Citation
Rong P, Yunusova Y, Wang J, Zinman L, Pattee GL, Berry JD, et al. (2016) Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. PLoS ONE 11(5): e0154971.
doi:10.1371/journal.pone.0154971