Loading...
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection
Moore, Blake P. Chung, Dong-Hoon Matharu, Daljit S. Golden, Jennifer E. Maddox, Clinton Rasmussen, Lynn Noah, James W. Sosa, Melinda Ananthan, Subramaniam Tower, Nichole A.
Moore, Blake P.
Chung, Dong-Hoon
Matharu, Daljit S.
Golden, Jennifer E.
Maddox, Clinton
Rasmussen, Lynn
Noah, James W.
Sosa, Melinda
Ananthan, Subramaniam
Tower, Nichole A.
Citations
Altmetric:
Abstract
A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC50 = 2.3 ± 0.8 µM) with marginal cytotoxicity (CC50 = 30.9 ± 1.1 µM) and reduced viral titer by 100-fold. Compared to ribavirin, sulfonylpyrrolidine 5o demonstrated an improved in vitro potency and selectivity index.
Description
Date
2012-10-25
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Collections
Files
Loading...
Matharu_2012.pdf
Adobe PDF, 1.66 MB
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Moore, B. P., Chung, D. H., Matharu, D. S., Golden, J. E., Maddox, C., Rasmussen, L., … Severson, W. E. (2012). (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection. Journal of Medicinal Chemistry, 55(20), 8582–8587. http://doi.org/10.1021/jm300612z