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Peptide Mediated Antimicrobial Dental Adhesive System
Xie, Sheng-Xue Boone, Kyle VanOosten, Sarah Kay Yuca, Esra Song, Linyong Ge, Xueping Ye, Qiang Spencer, Paulette Tamerler, Candan
Xie, Sheng-Xue
Boone, Kyle
VanOosten, Sarah Kay
Yuca, Esra
Song, Linyong
Ge, Xueping
Ye, Qiang
Spencer, Paulette
Tamerler, Candan
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Abstract
The most common cause for dental composite failures is secondary caries due to invasive bacterial colonization of the adhesive/dentin (a/d) interface. Innate material weakness often lead to an insufficient seal between the adhesive and dentin. Consequently, bacterial by-products invade the porous a/d interface leading to material degradation and dental caries. Current approaches to achieve antibacterial properties in these materials continue to raise concerns regarding hypersensitivity and antibiotic resistance. Herein, we have developed a multi-faceted, bio-functionalized approach to overcome the vulnerability of such interfaces. An antimicrobial adhesive formulation was designed using a combination of antimicrobial peptide and a ε-polylysine resin system. Effector molecules boasting innate immunity are brought together with a biopolymer offering a two-fold biomimetic design approach. The selection of ε-polylysine was inspired due to its non-toxic nature and common use as food preservative. Biomolecular characterization and functional activity of our engineered dental adhesive formulation were assessed and the combinatorial formulation demonstrated significant antimicrobial activity against Streptococcus mutans. Our antimicrobial peptide-hydrophilic adhesive hybrid system design offers advanced, biofunctional properties at the critical a/d interface.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2019-02-08
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MDPI
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Xie_2019.pdf
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Keywords
Antimicrobial peptide, Polylysine, Adhesive formulation, Hybrid interface, Dental composites
Citation
Xie, S.-X.; Boone, K.; VanOosten, S.K.; Yuca, E.; Song, L.; Ge, X.; Ye, Q.; Spencer, P.; Tamerler, C. Peptide Mediated Antimicrobial Dental Adhesive System. Appl. Sci. 2019, 9, 557.