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A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Weidenbacher, Payton A.-B. Sanyal, Mrinmoy Friedland, Natalia Tang, Shaogeng Arunachalam, Prabhu S. Hu, Mengyun Kumru, Ozan S. Morris, Mary Kate Fontenot, Jane Shirreff, Lisa
Weidenbacher, Payton A.-B.
Sanyal, Mrinmoy
Friedland, Natalia
Tang, Shaogeng
Arunachalam, Prabhu S.
Hu, Mengyun
Kumru, Ozan S.
Morris, Mary Kate
Fontenot, Jane
Shirreff, Lisa
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Abstract
While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly (or less frequent) booster vaccine, and as a primary vaccine for pediatric use including in infants.
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Date
2023-04-17
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Nature Research
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Keywords
Antibodies, Protein vaccines, SARS-CoV-2
Citation
Weidenbacher, P.AB., Sanyal, M., Friedland, N. et al. A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat Commun 14, 2149 (2023). https://doi.org/10.1038/s41467-023-37417-9