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Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants
Wisdom, Cate Chen, Casey Yuca, Esra Zhou, Yan Tamerler, Candan Snead, Malcolm L.
Wisdom, Cate
Chen, Casey
Yuca, Esra
Zhou, Yan
Tamerler, Candan
Snead, Malcolm L.
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Abstract
The rising use of titanium dental implants has increased the prevalence of peri-implant disease that shortens their useful life. A growing view of peri-implant disease suggests that plaque accumulation and microbiome dysbiogenesis trigger a host immune inflammatory response that destroys soft and hard tissues supporting the implant. The incidence of peri-implant disease is difficult to estimate, but with over 3 million implants placed in the USA alone, and the market growing by 500,000 implants/year, such extensive use demands additional interceptive approaches. We report a water-based, nonsurgical approach to address peri-implant disease using a bifunctional peptide film, which can be applied during initial implant placement and later reapplied to existing implants to reduce bacterial growth. Bifunctional peptides are based upon a titanium binding peptide (TiBP) optimally linked by a spacer peptide to an antimicrobial peptide (AMP). We show herein that dental implant surfaces covered with a bifunctional peptide film kill bacteria. Further, using a simple protocol for cleaning implant surfaces fouled by bacteria, the surface can be effectively recoated with TiBP-AMP to regain an antimicrobial state. Fouling, cleansing, and rebinding was confirmed for up to four cycles with minimal loss of binding efficacy. After fouling, rebinding with a water-based peptide film extends control over the oral microbiome composition, providing a novel nonsurgical treatment for dental implants.
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This is a post-peer-review, pre-copyedit version of an article published in JOM Journal of the Minerals, Metals and Materials Society. The final authenticated version is available online at: http://dx.doi.org/10.1007/s11837-019-03334-w.
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2019-01-01
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Springer Verlag
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Wisdom, C., Chen, C., Yuca, E., Zhou, Y., Tamerler, C., & Snead, M. L. (2019). Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants. JOM (Warrendale, Pa. : 1989), 71(4), 1271–1280. doi:10.1007/s11837-019-03334-w