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Herpes Simplex Virus 1 Upregulates p 35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons
Mostafa, Heba H. van Loben Sels, Jessica M. Davido, David J.
Mostafa, Heba H.
van Loben Sels, Jessica M.
Davido, David J.
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Abstract
The cyclin-dependent kinase 5 (CDK-5) activating protein, p35, is important for acute herpes simplex virus 1 (HSV-1) replication in mice. This report shows that HSV-1 increases p35 levels, changes the primary localization of CDK-5 from the nucleus to the cytoplasm, and enhances CDK-5 activity during lytic or acute infection. Infected neurons also stained positive for the DNA damage response (DDR) marker γH2AX. We propose that CDK-5 is activated by the DDR to protect infected neurons from apoptosis.
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2015-05
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American Society for Microbiology
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Mostafa HH, van Loben Sels JM, Davido DJ. 2015. Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons. J Virol 89:5171–5175. doi:10.1128/JVI.00106-15.