Loading...
Total Syntheses of Arylindolizidine Alkaloids (+)-Ipalbidine and (+)-Antofine
Niphakis, Micah James Georg, Gunda I.
Niphakis, Micah James
Georg, Gunda I.
Citations
Altmetric:
Abstract
This paper presents the first application of two recently developed reactions to natural product synthesis. The first method involves a 6-endo-trig cyclization to prepare a versatile chiral enaminone building block. The second is a direct C–H arylation reaction. As a showcase for the utility of these methods, (+)-antofine and (+)-ipalbidine were synthesized in only 8 steps and 24–26% overall yields.
Description
Date
2010-09-03
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Collections
Files
Loading...
Georg_2010.pdf
Adobe PDF, 463.27 KB
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Niphakis, M. J., & Georg, G. I. (2010). Total Syntheses of Arylindolizidine Alkaloids (+)-Ipalbidine and (+)-Antofine. The Journal of Organic Chemistry, 75(17), 6019–6022. http://doi.org/10.1021/jo101051w