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Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites.

Burrow, Allison A.
; 
Williams, Laura E.
; 
Pierce, Levi C. T.
; 
Wang, Yuh-Hwa
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Abstract
Gene rearrangements such as chromosomal translocations have been shown to contribute to cancer development. Human chromosomal fragile sites are regions of the genome especially prone to breakage, and have been implicated in various chromosome abnormalities found in cancer. However, there has been no comprehensive and quantitative examination of the location of fragile sites in relation to all chromosomal aberrations.
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2009-01-30
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BioMed Central
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Electrical Engineering and Computer Science Scholarly Works
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Burrow, Allison A, Laura E Williams, Levi C T Pierce, and Yuh-Hwa Wang. 2009. “Over Half of Breakpoints in Gene Pairs Involved in Cancer-Specific Recurrent Translocations Are Mapped to Human Chromosomal Fragile Sites.” BMC Genomics 10: 59. http://dx.doi.org/10.1186/1471-2164-10-59
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https://hdl.handle.net/1808/12765
DOI
10.1186/1471-2164-10-59
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