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Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease
Watts, Amber Crimmins, Eileen M. Gatz, Margaret
Watts, Amber
Crimmins, Eileen M.
Gatz, Margaret
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Abstract
Periodontal disease (PDD) is associated with increased risk of cardiovascular disease, cerebrovascular disease, and mortality in many studies, while other studies have begun to suggest an association of PDD with Alzheimer’s disease (AD). This paper discusses how infectious pathogens and systemic infection may play a role in AD. The roles of infection and inflammation are addressed specifically with regard to known AD pathologic lesions including senile plaques, neuron death, neurofibrillary tangles, and cerebrovascular changes. A testable model of proposed pathways between periodontal infection and AD is presented including three possible mechanisms: a) direct effects of infectious pathogens, b) inflammatory response to pathogens, and c) the effects on vascular integrity. The role of gene polymorphisms is discussed, including apolipoprotein (APOE) ε4 as a pro-inflammatory and pro-infection genotype.
Description
This is the publisher's version, also available electronically from http://www.dovepress.com/inflammation-as-a-potential-mediator-for-the-association-between-perio-peer-reviewed-article-NDT.
Date
2008-09-10
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Dove Medical Press
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Keywords
Periodontal disease, Infection, Inflammation, Alzheimer's disease
Citation
Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret. (2008). "Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease." Neuropsychiatric Disease and Treatment, 4(6):865-876. http://dx.doi.org/10.2147/NDT.S3610.