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SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides
Rolfe, Alan Samarakoon, Thiwanka Bandara Klimberg, Sarra V. Brzozowski, Marek Neuenswander, Benjamin Lushington, Gerald H. Hanson, Paul R.
Rolfe, Alan
Samarakoon, Thiwanka Bandara
Klimberg, Sarra V.
Brzozowski, Marek
Neuenswander, Benjamin
Lushington, Gerald H.
Hanson, Paul R.
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Abstract
The construction of a library of benzothiaoxazepine-1,1’-dioxides utilizing a one-pot, SNAr diversification – ODCT50 scavenging protocol is reported. This protocol combines microwave irradiation to facilitate the reaction, in conjunction with a soluble ROMP-derived scavenger (ODCT) to afford the desired products in good overall purity. Utilizing this protocol, a 78-member library was successfully synthesized and submitted for biological evaluation.
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Combinatorial Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/cc1001023.
Date
2010-11-08
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American Chemical Society
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Keywords
Sultams, SNAr, Microwave, ODCT, ROMP, Scavenging
Citation
Rolfe, A., Samarakoon, T. B., Klimberg, S. V., Brzozowski, M., Neuenswander, B., Lushington, G. H., & Hanson, P. R. (2010). SNAr-Based, facile synthesis of a library of Benzothiaoxazepine-1,1’-dioxides. Journal of Combinatorial Chemistry, 12(6), 850–854. http://doi.org/10.1021/cc1001023