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Parallel solid-phase synthesis of diaryltriazoles
Wrobel, Matthias Aubé, Jeffrey König, Burkhad
Wrobel, Matthias
Aubé, Jeffrey
König, Burkhad
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Abstract
A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein–protein interactions.
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Date
2012-07-06
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Beilstein-Institut
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Wrobel_2012.pdf
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Keywords
Chemical diversity, Huisgen cycloaddition, Library synthesis, Peptidomimetics, Solid phase synthesis, Triazole
Citation
Wrobel, Matthias, Jeffrey Aube, and Burkhard Konig. 2012. “Parallel Solid-Phase Synthesis of Diaryltriazoles.” Beilstein Journal of Organic Chemistry 8 : 1027–36. http://dx.doi.org/10.3762/bjoc.8.115