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Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Schöneich, Christian
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Abstract
Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2019-11-28
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MDPI
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Pharmaceutical Chemistry Scholarly Works
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Schöneich_2019.pdf
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Keywords
Protein stability, Therapeutic proteins, Thiyl radicals, Oxidation, Fragmentation, Cross-link
Citation
Schöneich C. (2019). Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins. Molecules (Basel, Switzerland), 24(23), 4357. https://doi.org/10.3390/molecules24234357
URI
https://hdl.handle.net/1808/30463
DOI
10.3390/molecules24234357
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