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Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates
Ambler, Brett R. Peddi, Santosh Altman, Ryan A.
Ambler, Brett R.
Peddi, Santosh
Altman, Ryan A.
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Abstract
The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.
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Date
2015-07-15
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Thieme Publishing
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altman_copper.pdf
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Keywords
Copper, Catalysis, Trifluoromethylation, Decarboxylation, Alkynes
Citation
Altman, Ryan, Brett Ambler, and Santosh Peddi. "Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates." Synthesis 46.14 (2014): 1938-946.