Loading...
Detection of cocaine induced rat brain activation by photoacoustic tomography
Jo, Janggun Yang, Xinmai
Jo, Janggun
Yang, Xinmai
Citations
Altmetric:
Abstract
Photoacoustic tomography (PAT) was used to detect the progressive changes on the cerebral cortex of Sprague Dawley rats after the administration of cocaine hydrochloride. Different concentrations (0, 2.5, and 5.0 mg per kg body) of cocaine hydrochloride in saline solution were injected into Sprague Dawley rats through tail veins. Cerebral cortex images of the animals were continuously acquired by PAT. For continuous observation, PAT system used multi-transducers to reduce the scanning time and maintain a good signal-to-noise ratio (SNR). The obtained photoacoustic images were compared with each other and confirmed that changes in blood volume were induced by cocaine hydrochloride injection. The results demonstrate that PAT may be used to detect the effects of drug abuse-induced brain activation.
Description
Date
2011-02-15
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Photoacoustic tomography, Imaging, Cocaine, Drug abuse, Brain, Cerebral cortex
Citation
Jo, J., & Yang, X. (2011). Detection of cocaine induced rat brain activation by photoacoustic tomography. Journal of Neuroscience Methods, 195(2), 232–235. http://doi.org/10.1016/j.jneumeth.2010.12.006