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A low-cost open-source SNP genotyping platform for association mapping applications
Macdonald, Stuart J. Pastinen, Tomi Genissel, Anne Cornforth, Theodore W. Long, Anthony D.
Macdonald, Stuart J.
Pastinen, Tomi
Genissel, Anne
Cornforth, Theodore W.
Long, Anthony D.
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Abstract
Association mapping aimed at identifying DNA polymorphisms that contribute to variation in
complex traits entails genotyping a large number of single-nucleotide polymorphisms (SNPs) in a
very large panel of individuals. Few technologies, however, provide inexpensive high-throughput
genotyping. Here, we present an efficient approach developed specifically for genotyping large fixed
panels of diploid individuals. The cost-effective, open-source nature of our methodology may make
it particularly attractive to those working in nonmodel systems.
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2005-12-02
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BioMed Central
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macdonald_low-cost.pdf
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Macdonald, S.J., Pastinen, T., Genissel, A., Cornforth, T.W., and Long, A.D. A low-cost open-source SNP genotyping platform for association mapping applications. Genome Biology 2005, 6:R105. http://dx.doi.org/10.1186/gb-2005-6-12-r105