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Branched amphiphilic peptide capsules: Cellular uptake and retention of encapsulated solutes
Sukthankar, Pinakin Avila, L. Adriana Whitaker, Susan K. Iwamoto, Takeo Morgenstern, Alfred Apostolidis, Christos Liu, Ke Hanzlik, Robert P. Dadachova, Ekaterina Tomich, John M.
Sukthankar, Pinakin
Avila, L. Adriana
Whitaker, Susan K.
Iwamoto, Takeo
Morgenstern, Alfred
Apostolidis, Christos
Liu, Ke
Hanzlik, Robert P.
Dadachova, Ekaterina
Tomich, John M.
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Abstract
Branched amphiphilic peptide capsules (BAPCs) are peptide nanospheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bi-layer delimited capsules. In two recent publications we described the lipid analogous characteristics of our BAPCs, examined their initial assembly, mode of fusion, solute encapsulation, and resizing and delineated their capability to be maintained at a specific size by storing them at 4 °C. In this report we describe the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs in vivo. The ability of our constructs to retain alpha particle emitting radionuclides without any apparent leakage and their persistence in the peri-nuclear region of the cell for extended periods of time, coupled with their ease of preparation and potential tune-ability, makes them attractive as biocompatible carriers for targeted cancer therapy using particle emitting radioisotopes. This article is part of a Special Issue entitled: Interfacially active peptides and proteins.
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Date
2014-02-22
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Elsevier
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Keywords
Peptide capsule, BAPC, Self-assembling peptide, Nanocapsule, 225Actinium, Alpha particle therapy
Citation
Sukthankar, Pinakin, L. Adriana Avila, Susan K. Whitaker, Takeo Iwamoto, Alfred Morgenstern, Christos Apostolidis, Ke Liu, Robert P. Hanzlik, Ekaterina Dadachova, and John M. Tomich. "Branched Amphiphilic Peptide Capsules: Cellular Uptake and Retention of Encapsulated Solutes." Biochimica Et Biophysica Acta (BBA) - Biomembranes 1838.9 (2014): 2296-305.