Loading...
Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans
Yaegashi, Junko Praseuth, Mike B. Tyan, Shaiw-Wei Sanchez, James F. Entwistle, Ruth A. Chiang, Yi-Ming Oakley, Berl R. Wang, Clay C. C.
Yaegashi, Junko
Praseuth, Mike B.
Tyan, Shaiw-Wei
Sanchez, James F.
Entwistle, Ruth A.
Chiang, Yi-Ming
Oakley, Berl R.
Wang, Clay C. C.
Citations
Altmetric:
Abstract
Aspernidine A is a prenylated isoindolinone alkaloid isolated from the model fungus Aspergillus nidulans. A genome-wide kinase knock out library of A. nidulans was examined and it was found that a mitogen-activated protein kinase gene, mpkA, deletion strain produces aspernidine A. Targeted gene deletions were performed in the kinase deletion background to identify the gene cluster for aspernidine A biosynthesis. Intermediates were isolated from mutant strains which provided information about the aspernidine A biosynthesis pathway.
Description
Date
2013-06-07
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Collections
Archive Status
This item contains archived web content.
Files
Loading...
Oakley_2013.pdf
Adobe PDF, 929.3 KB
Research Projects
Organizational Units
Journal Issue
Keywords
Citation
Yaegashi, J., Praseuth, M. B., Tyan, S.-W., Sanchez, J. F., Entwistle, R., Chiang, Y.-M., … Wang, C. C. C. (2013). Molecular Genetic Characterization of the Biosynthesis Cluster of a Prenylated Isoindolinone Alkaloid Aspernidine A in Aspergillus nidulans. Organic Letters, 15(11), 2862–2865. http://doi.org/10.1021/ol401187b