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Selenium and the Methionine Sulfoxide Reductase System
Oien, Derek B. Moskovitz, Jackob
Oien, Derek B.
Moskovitz, Jackob
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Abstract
Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed.
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license
Date
2009-07-01
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Publisher
MDPI
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Keywords
Selenoprotein, Methionine sulfoxide, Oxidative stress, Antioxidants, Posttranslational modification
Citation
Oien, D. B., & Moskovitz, J. (2009). Selenium and the methionine sulfoxide reductase system. Molecules (Basel, Switzerland), 14(7), 2337–2344. https://doi.org/10.3390/molecules14072337