Loading...
Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly
Mozziconacci, Olivier Williams, Todd D. Schöneich, Christian
Mozziconacci, Olivier
Williams, Todd D.
Schöneich, Christian
Citations
Altmetric:
Abstract
Glutathione thiyl radicals (GS•) were generated in H2O and D2O by either exposure of GSH to AAPH#, photoirradiation of GSH in the presence of acetone, or photoirradiation of GSSG. Detailed interpretation of the fragmentation pathways of deuterated GSH and GSH-derivatives during mass spectrometry analysis allowed us to demonstrate that reversible intramolecular H-atom transfer reactions between GS• and C-H bonds at Cys[αC], Cys[βC], and Gly[αC] are possible.
Description
This document is the Accepted Manuscript version of a Published Work that appeared in final form in
Chemical Research in Toxicology, copyright © American Chemical Society after peer review and technical editing by the publisher.
To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/tx3000494
Date
2012-09-17
Journal Title
Journal ISSN
Volume Title
Publisher
ACS
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Glutathione, Thiyl radicals, C-centered radical, Hydrogen transfer, Mass spectrometry
Citation
Mozziconacci, O., Williams, T. D., & Schöneich, C. (2012). Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys and Gly. Chemical Research in Toxicology, 25(9), 1842–1861. http://doi.org/10.1021/tx3000494