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Multiplex DNA Typing of Short-Tandem-Repeat Loci on the Y Chromosome
Redd, Alan J. Clifford, Stephanie L. Stoneking, Mark
Redd, Alan J.
Clifford, Stephanie L.
Stoneking, Mark
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Abstract
To facilitate evolutionary and forensic studies of DNA
polymorphisms on the Y chromosome, we devised a
multiplex amplification procedure for short-tandemrepeat
(STR) loci. Four tetranucleotide STR loci
(DYS19, DYS390, DYS391, and DYS393) were simultaneously
amplified with FAM-labeled primers and
genotypes were determined with an automated DNA
sequencer. We typed 162 males from three U.S. populations
(African-Americans, European-Americans and
Hispanics) and found that the haplotype diversities
range from 0.920 to 0.969. This quadruplex system
provides a facile means of genotyping these Y chromosome
STRs, and should be useful in population
genetic and forensic applications.
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This is the published version. Copyright 1997 de Gruyter.
Date
1997-08
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De Gruyter
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Redd, Alan J., Stephanie L. Clifford, and Mark Stoneking. "Multiplex DNA Typing of Short-tandem-repeat Loci on the Y Chromosome." Biological Chemistry 378.8 (1997): 923-27.