Loading...
PHOTOACOUSTIC MICROSCOPY OF MALIGNANT MELANOMA IN THE IN VIVO MOUSE MODEL
Staley, Jacob W.
Staley, Jacob W.
Citations
Altmetric:
Abstract
Current imaging modalities such as magnetic resonance imaging (MRI), computed tomography (CT), optical coherent tomography (OCT), and ultrasound have various drawbacks when applied to imaging malignant tumors and associated angiogenesis. These drawbacks range from the need to use toxic contrast agents to a lack of penetration depth and sufficient contrast. Photoacoustic microscopy improves on these techniques by utilizing optical absorption of biological components and acquiring acoustic waves from optical stimulation, yielding high contrast, while retaining high resolution and sufficient depth penetration. To address the limitations of current imaging modalities, researchers are investigating the application of photoacoustic microscopy in the early detection of malignant tumors. This thesis presents the results of applying noninvasive photoacoustic microscopy to detect and track the progression of subcutaneous melanoma tumors and melanoma tumor growth in the brain of live mice in vivo, as well as demonstrating the use of NIR-dye as a contrast agent for future use with photoacoustic tumor imaging.
Description
Date
2010-07-15
Journal Title
Journal ISSN
Volume Title
Publisher
University of Kansas
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Biomedical engineering, Brain, Dye, Melanoma, Photoacoustic microscopy, Subcutaneous