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The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C-elegans
Struckhoff, Eric Charles Lundquist, Erik A.
Struckhoff, Eric Charles
Lundquist, Erik A.
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Abstract
Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of UNC-115 as a downstream cytoskeletal effector of Rac signaling in axon pathfinding. We show that unc-115 double mutants with ced-10 Rac, mig-2 Rac or unc-73 GEF but not with rac-2/3 Rac displayed synthetic axon pathfinding defects, and that loss of unc-115 function suppressed the formation of ectopic plasma membrane extensions induced by constitutively-active rac-2 in neurons. Furthermore, we show that UNC-115 can bind to actin filaments. Thus, UNC-115 is an actin-binding protein that acts downstream of Rac signaling in axon pathfinding.
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Date
2003-02
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COMPANY OF BIOLOGISTS LTD
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693.pdf
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Keywords
Rac, UNC-115, Actin-binding protein, Axon pathfinding
Citation
Struckhoff, EC; Lundquist, EA. The actin-binding protein UNC-115 is an effector of Rac signaling during axon pathfinding in C-elegans. DEVELOPMENT. FEB 2003. 130(4) : 693-704.