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Efflux transporters of the placenta
Young, Amber M. Allen, Courtni E. Audus, Kenneth L.
Young, Amber M.
Allen, Courtni E.
Audus, Kenneth L.
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Abstract
The use of pharmaceuticals during pregnancy is often a necessity for the health of the mother. Until recently, the placenta was viewed as a passive organ through which molecules are passed indiscriminately between mother and fetus. In reality, the placenta contains a plethora of transporters, some of which appear to be specifically dedicated to removal of xenobiotics and toxic endogenous compounds. Drug efflux transporters such as P-glycoprotein (P-gp), several multidrug resistant associated proteins (MRPs) and breast cancer resistant protein (BCRP) may provide mechanisms that protect the developing fetus. Bile acid transporters may also play a role in exporting compounds back into the maternal compartment. Steroid hormones directly influence the level of expression and function in some of these transporters. Investigating the link between the hormones of pregnancy and these drug efflux transporters is one possible key in developing strategies to deliver drugs to the mother with minimal fetal risk.
Description
This is the author's accepted manuscript, post peer review. For the published version, please see the link in this record.
Date
2003
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Publisher
Elsevier
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Research Projects
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Keywords
P-glycoprotein, MDR1, MRP, BCRP, Drug efflux, Placental barrier, Multidrug resistance
Citation
Young, A.M., Allen, C.E., and Audus, K.L.* (2003) Efflux transporters of the placenta. Advanced Drug Delivery Reviews 55, 125-132. PMID: 12535577