Loading...
Epithelial cell polarity and cell junctions in drosophila
Tepass, Ulrich TanentzapfÂ, Guy Ward, Robert E., IV Fehon, Richard G.
Tepass, Ulrich
TanentzapfÂ, Guy
Ward, Robert E., IV
Fehon, Richard G.
Citations
Altmetric:
Abstract
The polarized architecture of epithelial cells and tissues is a fundamental determinant of animal anatomy and physiology. Recent progress made in the genetic and molecular analysis of epithelial polarity and cellular junctions in Drosophila has led to the most detailed understanding of these processes in a whole animal model system to date. Asymmetry of the plasma membrane and the differentiation of membrane domains and cellular junctions are controlled by protein complexes that assemble around transmembrane proteins such as DE-cadherin, Crumbs, and Neurexin IV, or other cytoplasmic protein complexes that associate with the plasma membrane. Much remains to be learned of how these complexes assemble, establish their polarized distribution, and contribute to the asymmetric organization of epithelial cells.
Description
Date
2001-12
Journal Title
Journal ISSN
Volume Title
Publisher
Annual Review
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Epithelium, Cellular junctions, Polarity, Cellularization, membrane domain
Citation
Tepass, U, Tanentzapf G, Ward, RE, and Fehon, RG. Epithelial cell polarity and cell junctions in drosophila. Annual Review of Genetics. December 2001. 35(747) : 747-784.