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Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation
Williams, Kelli M. Dotson, Abby L. Otto, Amber R. Kohlmeier, Jacob E. Benedict, Stephen H.
Williams, Kelli M.
Dotson, Abby L.
Otto, Amber R.
Kohlmeier, Jacob E.
Benedict, Stephen H.
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Abstract
With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+ICAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.
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Date
2011-08-27
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Publisher
Elsevier
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Keywords
Costimulation, Naive T cell differentiation, Regulatory T cells, ICAM-1, CD28, Foxp3
Citation
Williams, Kelli M., Abby L. Dotson, Amber R. Otto, Jacob E. Kohlmeier, and Stephen H. Benedict. "Choice of Resident Costimulatory Molecule Can Influence Cell Fate in Human Naïve CD4 T Cell Differentiation." Cellular Immunology 271.2 (2011): 418-27.