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Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma
Zimmerman, Matthew McDonald, Stacey L. Ho-Liang, Hsin-Pin Porubsky, Patrick Nguyen, Quyen Pharr, Cameron W. Perkowski, Andrew J. Smith, Robert Schoenen, Frank J. Gold, Ben S.
Zimmerman, Matthew
McDonald, Stacey L.
Ho-Liang, Hsin-Pin
Porubsky, Patrick
Nguyen, Quyen
Pharr, Cameron W.
Perkowski, Andrew J.
Smith, Robert
Schoenen, Frank J.
Gold, Ben S.
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Abstract
A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2019-03-22
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Springer Nature
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Zimmerman, M., McDonald, S. L., Ho-Liang, H. P., Porubsky, P., Nguyen, Q., Pharr, C. W., Perkowski, A. J., Smith, R., Schoenen, F. J., Gold, B. S., Zhang, D., Nathan, C. F., Dartois, V., & Aubé, J. (2019). Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma. The Journal of antibiotics, 72(6), 469–475. https://doi.org/10.1038/s41429-019-0167-y