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Photoacoustic tomography of small animal brain with a curved array transducer
Yang, Xinmai Maurudis, Anastasios Gamelin, John Aguirre, Andres Zhu, Quing Wang, Lihong V.
Yang, Xinmai
Maurudis, Anastasios
Gamelin, John
Aguirre, Andres
Zhu, Quing
Wang, Lihong V.
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Abstract
We present the application of a curved array photoacoustic tomographic imaging system that can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system is optimized to produce a B-mode, 90-deg field-of-view image at sub-200-μm resolution at a frame rate of ∼1frame∕second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-deg scan can be achieved within 15s. In previous work, two-dimensional (2-D) ex vivo mouse brain cortex imaging has been reported. We report three-dimensional (3-D) small animal brain imaging obtained with the curved array system. The results are presented as a series of 2-D cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Last, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2-D imaging.
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This is the published version. Copyright © 2009 Society of Photo-Optical Instrumentation Engineers
Date
2009-09-16
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Society of Photo-optical Instrumentation Engineers
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Yang, Xinmai, Anastasios Maurudis, John Gamelin, Andres Aguirre, Quing Zhu, and Lihong V. Wang. "Photoacoustic Tomography of Small Animal Brain with a Curved Array Transducer." J. Biomed. Opt. Journal of Biomedical Optics 14.5 (2009): 054007. http://dx.doi.org/10.1117/1.3227035