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Prodrugs: Do They Have Advantages in Clinical Practice?
Stella, Valentino J. Charman, W. N. A. Naringrekar, V. H.
Stella, Valentino J.
Charman, W. N. A.
Naringrekar, V. H.
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Abstract
Prodrugs are pharmacologically inactive chemical derivatives of a drug molecule that require a transformation within the body in order to release the active drug. They are designed to overcome pharmaceutical and/or pharmacokinetically based problems associated with the parent drug molecule that would otherwise limit the clinical usefulness of
the drug.
The scientific rationale, based on clinical pharmaceutical and chemical experience,
for the design of various currently used prodrugs is presented in this review. The examples presented are by no means comprehensive, but are representative of the different ways in which the prodrug approach has been used to enhance the clinical efficacy of various drug molecules.
Description
This is the published version, also available from the publisher at http://adisonline.com/drugs/Abstract/1985/29050/Prodrugs__Do_They_Have_Advantages_in_Clinical.2.aspx
Date
1985-05
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Publisher
Adis Press Limited
Archive Status
This item contains archived web content.
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Keywords
Pro-drugs, Pharmaceutical chemistry
Citation
Prodrugs: Do They Have Advantages in Clinical Practice? V.J. Stella, W.N.A. Charman and V.H. Naringrekar, Drugs, 29, 455-473 (1985).