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Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol
Zang, Qin Zhou, Aihua Javed, Salim Maity, Pradip K. Knudtson, Christopher Anton Bi, Danse Hastings, Jared J. Basha, Fatima Z. Hanson, Paul R.
Zang, Qin
Zhou, Aihua
Javed, Salim
Maity, Pradip K.
Knudtson, Christopher Anton
Bi, Danse
Hastings, Jared J.
Basha, Fatima Z.
Hanson, Paul R.
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Abstract
A novel one-pot sulfonylation/intramolecular thia-Michael protocol is reported for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. Sulfonylation between cysteine ethyl ester/cysteamine and 2-chloroethanesulfonyl chloride, followed by in situ intramolecular thia-Michael addition, was achieved and afforded the titled 1,5,2-dithiazepine-1,1-dioxide scaffolds. Diversification was demonstrated for future library synthesis.
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2012-12-31
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Elsevier
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Zang_2012.pdf
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Zang, Q., Zhou, A., Javed, S., Maity, P. K., Knudtson, C. A., Bi, D., … Hanson, P. R. (2012). Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol. Heterocycles, 86(2), 10.3987/COM–12–S(N)121. http://doi.org/10.3987/COM-12-S(N)121