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Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity

Niraula, Suraj
; 
Hauser, William L.
; 
Rouse, Adam G.
; 
Subramanian, Jaichandar
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Abstract
Familiarity creates subjective memory of repeated innocuous experiences, reduces neural and behavioral responsiveness to those experiences, and enhances novelty detection. The neural correlates of the internal model of familiarity and the cellular mechanisms of enhanced novelty detection following multi-day repeated passive experience remain elusive. Using the mouse visual cortex as a model system, we test how the repeated passive experience of a 45° orientation-grating stimulus for multiple days alters spontaneous and non-familiar stimuli evoked neural activity in neurons tuned to familiar or non-familiar stimuli. We found that familiarity elicits stimulus competition such that stimulus selectivity reduces in neurons tuned to the familiar 45° stimulus; it increases in those tuned to the 90° stimulus but does not affect neurons tuned to the orthogonal 135° stimulus. Furthermore, neurons tuned to orientations 45° apart from the familiar stimulus dominate local functional connectivity. Interestingly, responsiveness to natural images, which consists of familiar and non-familiar orientations, increases subtly in neurons that exhibit stimulus competition. We also show the similarity between familiar grating stimulus-evoked and spontaneous activity increases, indicative of an internal model of altered experience.
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Date
2023-11-27
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Nature Research
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Pharmacy Scholarly Works
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41598_2023_Article_47957.pdf
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Keywords
Habituation, Visual system
Citation
Niraula S, Hauser WL, Rouse AG, Subramanian J. Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity. Sci Rep. 2023 Nov 27;13(1):20907. doi: 10.1038/s41598-023-47957-1. PMID: 38017135; PMCID: PMC10684504
URI
https://hdl.handle.net/1808/35119
DOI
10.1038%2Fs41598-023-47957-1
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