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Three-dimensional Macroscopic Scaffolds With a Gradient in Stiffness for Functional Regeneration of Interfacial Tissues
Singh, Milind Dormer, Nathan Henry Salash, Jean Remy Christian, Jordan M. Moore, David S. Berkland, Cory J. Detamore, Michael S.
Singh, Milind
Dormer, Nathan Henry
Salash, Jean Remy
Christian, Jordan M.
Moore, David S.
Berkland, Cory J.
Detamore, Michael S.
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Abstract
A novel approach has been demonstrated to construct biocompatible, macroporous 3-D tissue engineering scaffolds containing a continuous macroscopic gradient in composition that yields a stiffness gradient along the axis of the scaffold. Polymeric microspheres, made of poly(d,l-lactic-co-glycolic acid) (PLGA), and composite microspheres encapsulating a higher stiffness nano-phase material (PLGA encapsulating CaCO3 or TiO2 nanoparticles) were used for the construction of microsphere-based scaffolds. Using controlled infusion of polymeric and composite microspheres, gradient scaffolds displaying an anisotropic macroscopic distribution of CaCO3/TiO2 were fabricated via an ethanol sintering technique. The controllable mechanical characteristics and biocompatible nature of these scaffolds warrants further investigation for interfacial tissue engineering applications.
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Date
2010-09-01
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Wiley
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Dormer_2010.pdf
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Keywords
Gradient, Interfacial tissue, Tissue engineering, Composite materials, Stiffness
Citation
Singh, M., Dormer, N., Salash, J. R., Christian, J. M., Moore, D. S., Berkland, C. and Detamore, M. S. (2010), Three-dimensional macroscopic scaffolds with a gradient in stiffness for functional regeneration of interfacial tissues. J. Biomed. Mater. Res., 94A: 870–876. doi:10.1002/jbm.a.32765