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Evaluation of fracture risk and potential drug holidays for postmenopausal women on long-term bisphosphonate therapy
Kostoff, Matthew D. Saseen, Joseph J. Borgelt, Laura M.
Kostoff, Matthew D.
Saseen, Joseph J.
Borgelt, Laura M.
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Abstract
Study objective: To describe characteristics of postmenopausal women on long-term bisphosphonate therapy who fall into one of four fracture risk categories (low, mild, moderate, high), and to determine the prevalence of women eligible for a drug holiday.
Design: Retrospective electronic health record review.
Setting: Eight primary care clinics within a university-based health care system.
Patients: A total of 201 postmenopausal women of ages 55–89 years, with osteopenia or osteoporosis, prescribed bisphosphonate therapy for >4 years, between October 10, 2002 and September 9, 2012.
Main results: The patients' mean age was 71.4 (±8.2) years; their mean body mass index was 25.3 (±5.6) kg/m2; and 73.1% were white. Seventy-four out of 201 patients (36.8%) were low-risk; 10/201 (5.0%) were mild-risk; 72/201 (35.8%) were moderate-risk; and 45/201 (22.4%) were high-risk. Eighty-one women (40.3%) were eligible for a drug holiday or discontinuation. The estimated drug cost avoided per eligible patient was $574.80. Calcium and/or vitamin D supplementation was documented in 52.7% of women.
Conclusion: More than one-third of postmenopausal women taking long-term bisphosphonate therapy had low fracture risk, and over 40% of our patients were eligble for a drug holiday or discontinuation. These data emphasize the need to accurately assess risk and benefit in patients treated with bisphosphonate therapy.
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This is the publisher's version, also available electronically from http://www.dovepress.com/evaluation-of-fracture-risk-and-potential-drug-holidays-for-postmenopa-peer-reviewed-article-IJWH
Date
2014-04-28
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Dove Medical Press
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Keywords
postmenopausal osteoporosis, Bisphosphonates, Drug holiday, Fracture
Citation
Kostoff, Matthew D. et al. (2014). E
valuation of fracture risk and potential
drug holidays for postmenopausal women
on long-term bisphosphonate therapy. International Journal of Women's Health 6:423-428. http://dx.doi.org/10.2147/IJWH.S57549