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A chromosome-level genome assembly of Cydia pomonella provides insights into chemical ecology and insecticide resistance
Wan, Fanghao Yin, Chuanlin Tang, Rui Chen, Maohua Wu, Qiang Huang, Cong Qian, Wanqiang Rota-Stabelli, Omar Yang, Nianwan Wang, Shuping
Wan, Fanghao
Yin, Chuanlin
Tang, Rui
Chen, Maohua
Wu, Qiang
Huang, Cong
Qian, Wanqiang
Rota-Stabelli, Omar
Yang, Nianwan
Wang, Shuping
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Abstract
The codling moth Cydia pomonella, a major invasive pest of pome fruit, has spread around the globe in the last half century. We generated a chromosome-level scaffold assembly including the Z chromosome and a portion of the W chromosome. This assembly reveals the duplication of an olfactory receptor gene (OR3), which we demonstrate enhances the ability of C. pomonella to exploit kairomones and pheromones in locating both host plants and mates. Genome-wide association studies contrasting insecticide-resistant and susceptible strains identify hundreds of single nucleotide polymorphisms (SNPs) potentially associated with insecticide resistance, including three SNPs found in the promoter of CYP6B2. RNAi knockdown of CYP6B2 increases C. pomonella sensitivity to two insecticides, deltamethrin and azinphos methyl. The high-quality genome assembly of C. pomonella informs the genetic basis of its invasiveness, suggesting the codling moth has distinctive capabilities and adaptive potential that may explain its worldwide expansion.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2019-09-17
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Nature Research
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Wan_2019.pdf
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Entomology, Genomics
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Wan, F., Yin, C., Tang, R. et al. A chromosome-level genome assembly of Cydia pomonella provides insights into chemical ecology and insecticide resistance. Nat Commun 10, 4237 (2019). https://doi.org/10.1038/s41467-019-12175-9