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Programmable active droplet generation enabled by integrated pneumatic micropumps
Zeng, Yong Shin, Mimi Wang, Tanyu
Zeng, Yong
Shin, Mimi
Wang, Tanyu
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Abstract
In this work we have investigated the integrated diaphragm micropump as an active fluidic control
approach for the on-demand generation of droplets with precisely defined size, frequency and timing. In
contrast to valve-actuated devices that only modulate the flow of the dispersed phase being continuously
injected, this integrated micropump allows the combination of fluidic transport and modulation to achieve
active control of droplet generation. A distinct characteristic of this method compared to the valve
modulated droplet formation processes is that it enables independent control of droplet generation
frequency by adjusting the pumping frequency and droplet size by flow conditions. We also demonstrated
the generation of complex droplet patterns through programming the pumping configurations and the
application to multi-volume digital PCR for precise and quantitative detection of genetic targets. Overall,
our results suggest that the pump-based droplet microfluidics provide a robust platform for
programmable active droplet generation which could facilitate the development of high-performance
chemical and biological assays.
Description
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author’s publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of the Provost, Dr. Jeffrey Vitter; Vice Chancellor for Research & Graduate Studies, Dr. Steve Warren; Acting KUMC Executive Vice Chancellor, Dr. Steve Stites; and Dr. Paul Terranova, KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml. This journal is The Royal Society of Chemistry 2013. When the author signs the exclusive Licence to Publish for a journal article, he/she retains certain rights that may be exercised without reference to the RSC. He/she may:
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Date
2013
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Zeng, Yong; Shin, Mimi; and Wang, Tanyu. (2013) Programmable active droplet generation enabled by
integrated pneumatic micropumps. Lab on a Chip, 13, 267.