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Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs
Frau, Roberto Orrù, Marco Puligheddu, Monica Gessa, Gian Luigi Mereu, Giampaolo Marrosu, Francesco Bortolato, Marco
Frau, Roberto
Orrù, Marco
Puligheddu, Monica
Gessa, Gian Luigi
Mereu, Giampaolo
Marrosu, Francesco
Bortolato, Marco
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Abstract
Sleep deprivation (SD) is known to induce perceptual impairments, ranging from perceptual distortion to hallucinatory states. Although this phenomenon has been extensively described in the literature, its neurobiological underpinnings remain elusive. In rodents, SD induces a series of behavioural patterns that might be reflective of psychosis and mania, such as hyperlocomotion and sensitization to psychotogenic drugs. Notably, such changes are accompanied by transitory alterations of dopaminergic signalling. Based on the hypothesis that both psychotic and manic disorders reflect gating impairments, the present study was aimed at the assessment of the impact of SD on the behavioural model of prepulse inhibition (PPI) of the startle reflex, a reliable paradigm for the study of informational filtering. Rats subjected to SD (24 h, 48 h, 72 h) exhibited a time-dependent increase in startle reflex and a dramatic deficit in PPI. Both alterations were reversed 24 h after termination of the SD period. Interestingly, PPI disruption was efficiently prevented by haloperidol (0.1 mg/kg i.p.) clozapine (5 mg/kg i.p.) and risperidone (1 mg/kg i.p.). Conversely, neither the anxiolytic diazepam (5 mg/kg i.p.) nor the antidepressant citalopram (5 mg/kg i.p) affected the PPI disruption mediated by SD, although diazepam reversed the enhancement in startle reflex magnitude induced by this manipulation. Our data suggest that SD induces gating deficits that might be relevant to the hallucinatory phenomena observed in humans, and provide a novel reliable animal model where such relationship can be studied.
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This is the publisher's version, also available electronically from http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=2327016&fileId=S1461145708008900
Date
2008-11
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Cambridge University Press
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Keywords
Clozapine, Haloperidol, Prepulse inhibition of the startle, risperidone, Sleep deprivation
Citation
Frau, Roberto et al. (2008). Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs. The International Journal of Neuropsychopharmacology 11(7):947-955. http://dx.doi.org/10.1017/S1461145708008900