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Antiproliferative Withanolides from Datura wrightii
Zhang, Huaping Bazzill, Joseph Gallagher, Robert J. Subramanian, Chitra Grogan, Patrick T. Day, Victor W. Kindscher, Kelly Cohen, Mark S. Timmermann, Barbara N.
Zhang, Huaping
Bazzill, Joseph
Gallagher, Robert J.
Subramanian, Chitra
Grogan, Patrick T.
Day, Victor W.
Kindscher, Kelly
Cohen, Mark S.
Timmermann, Barbara N.
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Abstract
A new withanolide, named withawrightolide (1), and four known withanolides (2−5) were isolated from the aerial parts of Datura wrightii. The structure of compound 1 was elucidated through 2D NMR and other spectroscopic techniques. In addition, the structure of withametelin L (2) was confirmed by X-ray crystallographic analysis. Using MTS viability assays, withanolides 1−5 showed antiproliferative activities against human glioblastoma (U251 and U87), head and neck squamous cell carcinoma (MDA-1986), and normal fetal lung fibroblast (MRC-5) cells with IC50 values in the range between 0.56 and 5.6 μM.
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2012-12-19
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Journal of Natural Products
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Zhang, Huaping, Joseph Bazzill, Robert J. Gallagher, Chitra Subramanian, Patrick T. Grogan, Victor W. Day, Kelly Kindscher, Mark S. Cohen, and Barbara N. Timmermann. "Antiproliferative Withanolides FromDatura Wrightii." Journal of Natural Products 76.3 (2013): 445-49.