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More than two decades of Apc modeling in rodents
Zeineldin, Maged Neufeld, Kristi L.
Zeineldin, Maged
Neufeld, Kristi L.
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Abstract
Mutation of tumor suppressor gene adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently developed, phenotypic variation among different models, and genotype/phenotype correlations.
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Date
2013-01-17
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Elsevier
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Keywords
Adenomatous polyposis coli/APC, Apc mouse model, FAP model, Conditional Apc mutation, Intestinal polyposis, LOH/Apc mouse model
Citation
Zeineldin, M., & Neufeld, K. L. (2013). More than two decades of Apc modeling in rodents. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1836(1), 80-89.