Loading...
Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol
Motiwala, Hashim F. Yin, Qin Aubé, Jeffrey
Motiwala, Hashim F.
Yin, Qin
Aubé, Jeffrey
Citations
Altmetric:
Abstract
The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.
Description
This work is licensed under a Creative Commons Attribution 4.0 International License.
Date
2015-12-29
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Collections
Research Projects
Organizational Units
Journal Issue
Keywords
Schmidt reaction, Aldehydes, Nitriles, HFIP
Citation
Motiwala, H. F., Yin, Q., & Aubé, J. (2015). Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol. Molecules (Basel, Switzerland), 21(1), E45. https://doi.org/10.3390/molecules21010045