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Development of libraries inspired by sparteine
Singh, Gurpreet
Singh, Gurpreet
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Abstract
This thesis describes the development of libraries inspired by the natural product sparteine. Multi-gram synthesis of important intermediate representing sparteine core has been carried out. A scalable process has been developed based on the previously reported total synthesis of (+)-sparteine from Aubé's group. Libraries were produced via parallel synthesis and submitted to NIH Molecular Libraries-Small Molecule Repository for biological screening.
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Date
2011-21-31
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University of Kansas
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Organic chemistry